Alkylating Agents
HardPharmacology · Chemotherapy
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Alkylating agents are among the oldest and most heavily tested classes of cytotoxic anticancer drugs. They act by transferring alkyl groups to nucleophilic sites (especially N-7 of guanine) in DNA, producing cross-links that block replication. For NEET PG, the examiner rarely asks mechanism in isolation — the high-yield gold is the organ-specific toxicity of individual drugs and their antidotes/rescue agents. An a…
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