Aminoglycosides
ModeratePharmacology · Antimicrobials
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Aminoglycosides are bactericidal antibiotics that bind the 30S ribosomal subunit, cause mRNA misreading, and kill chiefly aerobic gram-negative bacilli. They are concentration-dependent killers with a post-antibiotic effect, hence the modern once-daily dosing. Their fame in exams rests on two toxicities — nephrotoxicity (reversible) and ototoxicity (irreversible) — and their synergy with beta-lactams. The clinical…
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