Porphyrin Metabolism & Haem Synthesis

Haem is an iron–protoporphyrin IX complex that anchors haemoglobin, myoglobin, the cytochromes, catalase, peroxidase and nitric oxide synthase. This topic links a tightly regulated 8-step biosynthetic pathway to a clinically rich family of porphyrias and to bilirubin handling — a perennial NEET PG favourite where one enzyme defect predicts the entire clinical picture. A porphyrin is a cyclic tetrapyrrole — four py…