Chronic Myeloproliferative Disorders
ModeratePathology · Haematology
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Chronic myeloproliferative disorders (now called myeloproliferative neoplasms, MPNs) are clonal stem-cell disorders in which one or more myeloid lineages (granulocytic, erythroid, megakaryocytic) proliferate without maturation arrest — so the marrow is hypercellular and the blood shows increased mature cells. This is the single biggest distinction from acute leukaemia (which has a maturation block and blast accumulat…
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