Cystic Fibrosis

Cystic fibrosis (CF) is the commonest lethal autosomal recessive disorder in Caucasians, caused by mutations in the CFTR gene that cripple chloride transport across epithelia, producing thick, viscid secretions in the lung, pancreas, gut, liver and reproductive tract. It is a favourite NEET PG topic because the genetics, the sweat chloride cut-off, meconium ileus and the new CFTR-modulator drugs are all tightly testa…