Liver Pathology — Hepatitis & Cirrhosis — Practice
A 55-year-old man with chronic hepatitis C develops a solitary 4 cm liver nodule. Serum alpha-fetoprotein is 850 ng/mL. The investigation-of-choice imaging shows a hypervascular lesion with arterial enhancement and venous washout. Which gross and microscopic feature most characteristically accompanies this malignancy?
ASpindle cell storiform pattern
BPropensity for vascular invasion of the portal vein
CPsammoma body formation
DSignet-ring cell morphology