Myasthenia Gravis

Myasthenia gravis (MG) is the prototype autoimmune disorder of the neuromuscular junction (NMJ), characterised by antibody-mediated destruction of post-synaptic acetylcholine receptors (AChR). The clinical hallmark is fatigable, fluctuating skeletal muscle weakness that worsens with sustained activity and improves with rest — a fact that drives almost every exam question on this topic. MG is a post-synaptic, antib…