Sickle Cell Disease in Children

Sickle cell disease (SCD) is the commonest clinically significant haemoglobinopathy worldwide and a recurring NEET PG favourite in Paediatrics and Haematology. The single point mutation in the β-globin gene produces a haemoglobin that polymerises on deoxygenation, sickles the red cell, and drives both chronic haemolysis and recurrent vaso-occlusion. This note builds the topic from the molecule up to the bedside crisi…