Systemic Lupus Erythematosus — Practice
A 27-year-old woman with systemic lupus erythematosus and a history of two second-trimester pregnancy losses develops a swollen left leg. She has a prolonged activated partial thromboplastin time that does not correct on mixing with normal plasma. Which antibody profile best confirms the underlying syndrome?
AAnti-histone antibodies
BAnti-double-stranded DNA and anti-Smith
CLupus anticoagulant, anticardiolipin and anti-beta-2-glycoprotein I
DAnti-Ro and anti-La