Thalassaemia
ModerateMedicine · Haematology
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Thalassaemias are a group of inherited (autosomal recessive) microcytic hypochromic anaemias caused by reduced or absent synthesis of one or more globin chains of haemoglobin. The defect is quantitative (chain production is decreased), in contrast to sickle cell disease where the defect is qualitative (an abnormal chain is made). They are the commonest monogenic disorders worldwide and are highly prevalent across the…
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